Amphetamine
AMP
Amphetamines are stimulants that speed up the body’s system. Many are legally prescribed and used to treat attention-deficit hyperactivity disorder (ADHD). Amphetamine was first marketed in the 1930s as Benzedrine® in an over-the-counter inhaler to treat nasal congestion. By 1937 amphetamine was available by prescription in tablet form and was used in the treatment of the sleeping disorder, narcolepsy, and ADHD. Over the years, the use and abuse of clandestinely produced amphetamines have spread. Today, clandestine laboratory production of amphetamines has mushroomed, and the abuse of the drug is on the rise.
Cut-Off Levels (ng/mL)
300, 500, 1,000 ng/mL (Urine)
<50, 50, 100 ng/mL (Saliva)
Window of Detection
From 2-5 hours after use up to 2-4 days (Urine)
1-3 Days (Saliva)
How is it Used?
Amphetamines are generally taken orally or injected. However, the addition of “ice,” the slang name of crystallized methamphetamine hydrochloride, has promoted smoking as another mode of administration. Just as “crack” is smokable cocaine, “ice” is smokable methamphetamine.
What are the Effects?
The effects of amphetamines and methamphetamine are similar to cocaine, but their onset is slower and their duration is longer. In contrast to cocaine, which is quickly removed from the brain and is almost completely metabolized, methamphetamine remains in the central nervous system longer, and a larger percentage of the drug remains unchanged in the body, producing prolonged stimulant effects. Chronic abuse produces a psychosis that resembles schizophrenia and is characterized by: Paranoia, picking at the skin, preoccupation with one’s own thoughts, and auditory and visual hallucinations. Violent and erratic behavior is frequently seen among chronic abusers of amphetamines and methamphetamine. Drugs that cause similar effects include: dexmethylphendiate, phentermine, benzphetamine, phendimetrazine, cocaine, crack, methamphetamine, and khat.
What does it look like?
Amphetamines are stimulant drugs that come in various forms depending on their preparation and use. Prescription amphetamines, such as Adderall and Dexedrine, are typically available as tablets or capsules for medical treatment, while illicit forms, commonly referred to as “speed” or “crystal meth,” are often found as powders, crystals, or pastes. Some amphetamines may also appear as liquids for injection. The appearance of amphetamines varies widely, with key forms outlined below:
- Powder: Fine, off-white, or pinkish powder.
- Crystals: Coarse granules resembling salt or sugar.
- Tablets: Small, colored pills with identifying imprints (prescription).
- Liquid: Dissolved form for injection (less common).
- Paste: Sticky, semi-solid substance (found in some illicit versions).
Packaging can range from labeled pharmaceutical containers for prescriptions to plastic bags or foil wraps for illicit products.
Common Symptoms of Use
Physical effects of amphetamine use include increased blood pressure and pulse rates, insomnia, loss of appetite, and physical exhaustion.
Overdose effects include agitation, increased body temperature, hallucinations, convulsions, and possible death.
Legal Status
Amphetamine are Schedule II stimulants, which means that they have a high potential for abuse and limited medical uses. Pharmaceutical products are available only through a prescription.
Rapid Testing Options
- Integrated Urine Test Cup
- Urine Dip Card Test
- Oral Fluid Test
- Field Test

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