Cross Reactivity
Cross reactivity is an important factor to consider in point of care toxicology testing. It refers to the potential for a substance to produce a positive test result for a different substance. Understanding cross reactivity is essential for accurate interpretation of test results and proper patient care. Healthcare professionals must be aware of the potential for cross reactivity and be able to distinguish between true positive test results and false positives caused by cross reactivity.
Top 5 Common Cross Reactions
Cross Reactivity Chart
Use the chart below to search for known cross reactions between substances. Search by substance, brand name, or results by typing into the search bar field. The chart will automatically filter results based on what is being and what has been typed.
| Substance | Common Brand Names | Results |
|---|---|---|
| Abacavir | Ziagen | Non-reactive |
| Acamprosate | Campral | Non-reactive |
| Acetaminophen (See also Paracetamol) | Aceta, Acephen, Apacet, Dapacen, Feverall, Tylenol, Excedrin (Combination), Panadol, Tempura | Non-reactive |
| Acetaminophen with Codeine (see also Paracetamol with codeine) | Tylenol 3, Tylenol with codeine | Positive for Opiates OPI, MOR |
| Acetic Acid | Ethanoic Acid | Non-reactive |
| Acetophenetidin | Phenacetin | Non-reactive |
| Acetylsalicyclic acid | Aspirin, Anadin, Anasin, Bufferin, Caprin, Disprin, Ecotrin, Empirin, Excedrin (combination) | Non-reactive |
| Aciclovir | Zovirax | Non-reactive |
| Adinazolam | Deracyn | Non-reactive |
| Albuterol (salbutamol) | Aerocrom, Aerolin, Airomir, Asmasal, Combivent, Duovent, Ventide, Ventodisks, Ventolin, Volmax | Non-reactive |
| Allobarbital | No known trade names | Positive for Barbiturates BAR |
| Alphenol | No known trade names | Positive for Barbiturates BAR |
| Alprazolam | Xanax | Positive for Benzodiazepines BZO |
| Aluminum Chloride Hexahydrate | Drichlor, Anhydrol Forte | Non-reactive |
| Aluminum Hydroxide | Alu-Cap, Alisone, Gastrocote, Kolanticon, Maalox, Maalox TC, Mucogel, Pyrogastrone, Topal | Non-reactive |
| Alverine Citrate | Spasmonal, Spasmonal Fibre | Non-reactive |
| Amitriptyline | Elavil, Lentizol, Tryptizol, Triptafen, Triptafen-M | Positive for Tricyclic Antidepressants TCA |
| Amlodipine | Caduet, Norvasc | Non-reactive |
| Ammonia/Ipeacuanha | Ipecac | Non-reactive |
| Amobarbital | Amytal, Tuinal | Positive for Barbiturates BAR |
| Amoxicillin or Amoxycillin | Amoxil, Amoram, Augmentin, Heliclear | Non-reactive |
| Ampicillin | Penbritin, Polycillin, Principen | Non-reactive |
| Amylmetacresol | Strepsils | Non-reactive |
| Anhydrol forte | Non-reactive | |
| Antabuse | Disulfiram | Non-reactive |
| Antazoline Sulphate | Otrivine-Anistin | Non-reactive |
| Antipyrine | 4-Dimethylaminoantipyrine | Non-reactive |
| Aprobarbital | Positive for Barbiturates BAR | |
| Aspirin | Bayer Aspirin, Excedrin, ASA, Angettes, Asasantin, Caprin | Non-reactive |
| Atenolol | Beta-adlat, Co-tenidone, Kalten, Tenben, Tenif, Tenoret 50, Tenorectic, Tenormin | Non-reactive |
| Atorvastatin | Lipitor | Non-reactive |
| Azlocillin | Securopen | Non-reactive |
| Baclofen | Lioresal, Kemstro | Non-reactive |
| Barbital | Positive for Barbiturates BAR | |
| Beclometasone | AeroBec, AeroBec Forte, Asmabec, Beclazone, Becloforte, Becodisks, Beconase, Becotide, Fillair, Nasobec, Qvar, Ventide, Zonivent | Non-reactive |
| Bendrofluazide | Aprinox, Cogaretic, Indertic, Inderex, Neo-Naclax, Neo-Naclax-K, Prestim, Tenben | Non-reactive |
| Benzalknonium | Bradosol | Non-reactive |
| Benzocaine | Americaine, Merocaine | Non-reactive |
| Benztropine | Cogentin | Non-reactive |
| Benzydamine | Difflam | Non-reactive |
| Benzylpenicillin | Crystapen | Non-reactive |
| Bromazepam | Lexotan | Positive for Benzodiazepines BZO |
| Bromopheniramine | Dimetapp, Dimotapp, Dimotane | Non-reactive |
| Budesonide | Entocort, Pulmicort, Rhinocort | Non-reactive |
| Buprenorphine | Subutex, Suboxone, Temgesic | Positive for Buprenorphine BUP |
| Buproprion | Wellbutrin, Zyban | Non-reactive |
| Buspirone | BuSpar, Vanspar | Positive for Fentanyl FYL |
| Butabarbital | Butisol, Soneryl | Positive for Barbiturates BAR |
| Butalbital | Fioricet, Fiorinal | Positive for Barbiturates BAR |
| Butethal | Positive for Barbiturates BAR | |
| Canestan | Canestan ear/skin/vaginitis/HC | Non-reactive |
| Carbamate | Pesticide | Non-reactive |
| Carbamazepine | Tegretol, Teril, Timonil | Non-reactive |
| Carisoprodol | Soma | Non-reactive |
| Celecoxib | Celebrex | Non-reactive |
| Cephalexin | Ceporex, Keflex | Non-reactive |
| Cetirizine | Zyrtec | Non-reactive |
| Cetylpyridinium | Cepacol mouth rinse | Non-reactive |
| Chloral Hydrate | Welldorm | Non-reactive |
| Chlorazepate | Tranxene | Positive for Benzodiazepines BZO |
| Chlordiazepoxide | Librium | Positive for Benzodiazepines BZO |
| Chlorhexidine Gluconate | Bactrigras, Cordsodyl, Chlorohex, CX Powder, Dermol, Hibicet, Hibiscrub, Hibisol, Hibitane, Instillagel, Naseptin, Nystaform, Serotulle, Steripod, Tisept, Unisept, Uriflex, Uro-Trainer | Non-reactive |
| Chloroform | Non-reactive | |
| Chlorpheniramine Maleate | Galpseud, Haymine, Piriton | Non-reactive |
| Chlorpromazine | Largactil | Non-reactive |
| Chlorprothixene | Cloxan, Fluanxol, Taractan, Truxal | Non-reactive |
| Cimetidine | Dyspamet, Tagamet, Zita | Non-reactive |
| Cinnarizine | Stugeron | Non-reactive |
| Ciprofloxacin | Cipro | Non-reactive |
| Citalopram | Cipramil | Non-reactive |
| Clobazam | Frisium | Positive for Benzodiazepines BZO |
| Clofibrate | Atromid-S | Non-reactive |
| Clomethazole | Chlormethiazole, Heminevrin | Non-reactive |
| Clonazepam | Clonopin, Klonopin, Rivotril | Positive for Benzodiazepines BZO |
| Clotrimazole | Lotrimin, Lotrisone, Mycelex | Non-reactive |
| Clozapine | Clozaril, Clopine, Zaponex | Non-reactive |
| Co-Amoxiclav | Augmentin, Augmentin Duo | Non-reactive |
| Co-danthramar | Dantron | Non-reactive |
| Codeine Phosphate | Codafen Continus, Codeine Linctus, Pediatric BP, Galcodine, Kapake, Migraleve, Solpadol, Tylex | Positive for Opiates OPI, MOR |
| Co-Fluampicil | Magnapen | Non-reactive |
| Combivir | Epivir | Non-reactive |
| Co-Phenotrope (atropine/diphenoxylate) | Lomotil, Trepergen | Non-reactive |
| Co-Trimoxazole | Non-reactive | |
| Cyclobenazprine | Flexeril | Positive for Tricyclic Antidepressants TCA |
| Cyclosporin | Neoral | Non-reactive |
| Cyprohetadine | Periactin | Positive for Tricyclic Antidepressants TCA |
| Cyproterone | Androcur, Cyprostat, Nioproxil, Progynova, Siterone | Non-reactive |
| d/l-Octopamine | No known trade names | Non-reactive |
| Dantrolene | Non-reactive | |
| Delorazepam | Briantum | Positive for Benzodiazepines BZO |
| Dequalinium | Dequadin | Non-reactive |
| Desmopressin | DDAVP, Minirin, Stimate | Non-reactive |
| Dexamethasone | Decadron, Dexa-Rhinaspray Duo, Maxidex, Maxidrol, Minims, Otomize, Sofradex | Non-reactive |
| Dexamphetamine Sulphate | Adderall, Adderall XR, Dexedrine | Positive for Amphetamine AMP |
| Dextropropoxyphene | Darvon, Darvocet, Co-proximal | Positive for Propoxyphene PPX |
| Diazepam | Diazemuls, Stesolid, Valclair, Valium | Positive for Benzodiazepines BZO |
| Diclofenac Sodium | Dicloflex, Diclomax, Motifene, Volraman, Volsaid, Voltarol | Non-reactive |
| Dicyclomine | Kolanticon, Merbentyl | Non-reactive |
| Didanosine | Videx | Non-reactive |
| Dihydrocodeine | DHC Continus, Paramol, Remedeine, Remedeine Forte | Positive for Opiates OPI, MOR |
| Diltiazem | Cardizem, Dilacor, Tiazac | Non-reactive |
| Dimethicone | Asilone, Fancorsil | Non-reactive |
| Dipenoxylate with Atropine | Lomotil | Non-reactive |
| Diphenhydramine | Benadryl, Medinex, Nytol, Panadol Night | Non-reactive |
| d-Methamphetamine HCL | Desoxyn, Methedrine, Methamprex | Positive for Methamphetamine mAMP |
| Docusate Sodium | Non-reactive | |
| Donepezil | Aricept | Non-reactive |
| Dopamine | Intropin | Non-reactive |
| Dothiepin | Prothiaden | Positive for Tricyclic Antidepressants TCA |
| Doxepin | Sinequan, Xepin | Positive for Tricyclic Antidepressants TCA |
| Doxycycline | Vibramycin, Vibramycin-D | Non-reactive |
| Doxylamine | Nyquil | Positive for Methadone MTD |
| Droperidol | Dridol, Droleptan, Inapsine | Non-reactive |
| Duloxetine | Cymbalta | Non-reactive |
| Efavirenz | Sustiva | Positive for Cannabinoids THC [Urinary metabolite(s) only; parent compound is non- reactive] |
| Enoxaparin | Clexane, Lovenox | Non-reactive |
| Erythromycin | Arpimycin, Benzymycin, Erycane, Erymax, Erythrocin, Erythroped, Ilosone, Isotrexin, Lactobinate, Stiemycin, Tiloryth, Zineryl | Non-reactive |
| Estazolam | ProSom | Positive for Benzodiazepines BZO |
| Ethambutol | Myambutol | Non-reactive |
| Ethylmorphine | Positive for Opiates OPI, MOR | |
| Fenofibrate | Tricor | Non-reactive |
| Ferrous Fumarate | Iron | Non-reactive |
| Flucloxacillin | Co-fluampicil, Floxapen, Magnapen | Non-reactive |
| Flumazenil | Romazicon | Non-reactive |
| Flunitrazepam | Rohypnol | Positive for Benzodiazepines BZO |
| Fluoxetine | Prozac, Sarafem | Non-reactive |
| Flupentixol Decanoate | Depixol, Fluanxol | Non-reactive |
| Fluphenazine | Prolixin | Non-reactive |
| Flurazepam | Dalmane | Non-reactive |
| Folic Acid | Non-reactive | |
| Fusidic Acid (Sodium Fusidate) | Fucithalmic, Fucibet, Fucidin | Non-reactive |
| Gamma-Hydroxybutyrate | GHB | Non-reactive |
| Gemfibrozil | Gemcor, Lopid | Non-reactive |
| Gentamicin Sulphate | Cidomycin, Genticin, Gentisone | Non-reactive |
| Gliclazide | Diamicron, Dianorm | Non-reactive |
| Halazepam | Alapryl, Paxipam, Pacinone | Positive for Benzodiazepines BZO |
| Haloperidol | Haldol | Non-reactive |
| Hepatitis B Vaccine | Non-reactive | |
| Hydrochlorothiazide | Hyzaar, Losartan | Non-reactive |
| Hydrocodone | Lorcet, Loratab, Vicodin | Positive for Opiates OPI, MOR and/or Oxycodone OXY |
| Hydrocortisone | Actinac, Alphaderm, Alphosyl-HC, Anugesic-HC, Anusol-HC, Calmurid-HC, Canesten-HC, Colioam, Daktacort, Dioderm, Econacort, Efortelan, Efcortesel, Eurax-HC, Gregoderm, Hydrocortistab, Hydrocortone, Mildison lipocream, Neo-cortef, Nystaform, Perinal, Proctofoam, Quinocort, Terra- cortil, Timodine, Uniroid-HC, Vioform-HC, Xyloproct | Non-reactive |
| Hydrocortisone-17-butyrate | Locoid, Locoid C | Non-reactive |
| Hydromorphone | Dilaudid, Hydrostat | Positive for Opiates OPI, MOR and/or Oxycodone OXY |
| Hydroxocobalamin | Vitamin B-12 | Non-reactive |
| Hydroxychloroquine | Plaquenil | Non-reactive |
| Hydroxyzine | Atarax, Ucerax | Non-reactive |
| Hyoscine butylbromide | Busocopan, Scopoderm | Non-reactive |
| Ibuprofen | Brufen, Codafen, Fenbid, Ibugel, Ibuspray, Motrin, Proflex | Non-reactive |
| Indomethacin | Flexin continus, Indocid, Indomod | Non-reactive |
| Interferon Alfa | Intron A, Roferon-A, Viraferon, Wellferon | Non-reactive |
| Isoniazide | INH | Non-reactive |
| Isosorbide Dinitrate | Angitak, Cedocard, Isocard, Isoket, Isordil, Sorbichew, Sorbitrate, Sorbid SA | Non-reactive |
| Ketoprofen | Orudis, Oruvail, Powergel | Non-reactive |
| Koalin and Morphine Mixture | Diocalm, Entersan, Opazimes | Positive for Opiates OPI, MOR |
| Lactulose | Duphalec, Lactugal | Non-reactive |
| Lamotrigine | Lamitcal | Positive for Phencyclidine PCP |
| Lansoprazole | Heliclear, Zoton | Non-reactive |
| Lisinopril | Carace, Zestril, Zestoretic | Non-reactive |
| l-Methamphetamine HCL | Vick's Inhaler | Positive for Methamphetamine mAMP |
| Lofepramine | Gamanil, Lomont | Positive for Tricyclic Antidepressants TCA |
| Lofexidine | Britoflex | Non-reactive |
| Loperamide | Imodium, Loperagen, Norimide | Non-reactive |
| Loratadine | Claritin | Non-reactive |
| Lorazepam | Ativan | Positive for Benzodiazepines BZO |
| Lormetazepam | Noctamide | Positive for Benzodiazepines BZO |
| Magnesium Alginate | Gaviscon | Non-reactive |
| Mannitol | Gaviscon | Non-reactive |
| Medazepam | Anxitol, Lerisum, Medacepan, Nobritol, Nobrium | Positive for Benzodiazepines BZO |
| Mefenamic Acid | Ponstan, Ponstel | Non-reactive |
| Meperidine | Demerol, Pethidine | Non-reactive |
| Methadone Hydrochloride | Dolophine, Methadose, Physetone | Positive for Methadone MTD |
| Methylenedioxyamphetamine (MDA) | Eve (slang), Love Drug (slang) | Positive for Amphetamine AMP and Ecstasy MDMA |
| Methylenedioxymethamphetamine (MDMA) | Adam (slang), Ecstasy (slang), XTC (slang) | Positive for Methamphetamine mAMP and Ecstasy MDMA |
| Methylenedioxymethamphetamine (MDMA) | E (slang) | Positive for Methamphetamine mAMP and Ecstasy MDMA |
| Metoclopramide | Reglan | Non-reactive |
| Metronidazole | Anabact, Elyzol, Flagyl, Metrogel, Metrolyl, Metrotop, Neuratop, Noritate, Rozex, Zidoval, Zymoet | Non-reactive |
| Morphine | Astramorph, Cyclimorph, Duramorph, Morcap, Morphine Sulfate, MS Contin, Oramorph, Roxanol, Severedol | Positive for Opiates MOR, OPI |
| Nadolol | Corgard, Corgaretic, Corgartic | Non-reactive |
| Naloxone | Narcan | Non-reactive |
| Naltrexone | Antaxone, Nalorex, Trexan, Vivitrol | Positive for Oxycodone OXY |
| Naproxen | Aleve, Condrotec, Napratec, Naprosen, Naprosyn, Nycopren, Synflex | Non-reactive |
| Nicotine | Nicoderm, Nicorette, Nicotinell, Nicotrol, Niquitin | Non-reactive |
| Nifedipine | Adalat, Nifecard, Nifar, Nif-ten, Procardia | Non-reactive |
| Nitrazepam | Mogadon, Somnite | Positive for Benzodiazepines BZO |
| Norethindrone | BiNovum, Brevinor, Climagest, Climesse, Elleste Duet, Estracombi, Evorel, Kliofem, Kliovance, Loestrin, Micronor, Norlutin, Noriday, Norimin, Norinyl, Noristat, Nuvelle, Ovysmen, TriNovum, Trisquens, Utovian | Non-reactive |
| Noscapine | Narcotine | Non-reactive |
| Olanzapine | Zyprexa | Non-reactive |
| Orphenadrine | Disipil, Norflex, Norgesic | Non-reactive |
| Oxazepam | Ox-pam, Serax | Positive for Benzodiazepines BZO |
| Oxymetazoline | Afrin, Neo-synephrine | Non-reactive |
| Oxytetracycline | Terra-Cortil, Terramycin, Trimovate | Non-reactive |
| Paracetamol (Acetaminophen) | Fortagesic, Paradote | Non-reactive |
| Paracetamol (Acetaminophen) /Codeine Preparations | Co-codamol, Codafen, Co-dydramol, Kapake, Remedine, Solpadol, Tylenol 3, Tylex | Positive for Opiates MOR, OPI |
| Paroxetine | Paxil, Seroxat | Non-reactive |
| Penicillin | Combicillin, Mefoxin | Non-reactive |
| Pentobarbital | Nembutal | Positive for Barbiturates BAR |
| Pericyazine | Amplan, Aolept, Apamin, Iryakin, Nemactil, Neulactil, Propetyl, Psycholept | Non-reactive |
| Phenobarbital | Donnatal | Positive for Barbiturates BAR |
| Phenobarbitone (see also Phenobarbital) | Luminal | Positive for Barbiturates BAR |
| Phenytoin | Dilantin, Epanutin, Epitard | Possible Positive for Barbiturates BAR: Urinary metabolite(s) only; parent compound is non-reactive |
| Pholcodine | Galenphol, Strong BP, Pavacol-D, Thebacon | Positive for Opiates MOR, OPI |
| Piperacillin | Pipracil, Tazobactam | Non-reactive |
| Prazepam | Centrax, Demetrin | Positive for Benzodiazepines BZO |
| Prednisolone | Delta-cortef, Econopred, Inflamase, Pediapred, Prelone | Non-reactive |
| Procaine | Novocain | Positive for Opiates OPI, MOP |
| Progesterol | Non-reactive | |
| Promethazine | Allerfen, Anergan, Antinaus, Aprobit, Avomine, Baymethzine, Diprozin, Fenergan, Methazine, Phenergen | Positive for Tricyclic Antidepressants TCA |
| Propranolol | Beta-Progane, Inderal, Inderetic, Inderex | Non-reactive |
| Pseudeophedrine | Afrinol, Expulin, Sudafed, Tylenol Cold (combination) | Non-reactive |
| Ranitidine | Pylorid, Zantac | Positive for Methamphetamine mAMP: Urinary metabolite(s) only; parent compound is non-reactive |
| Risperidone | Risperdal | Non-Reactive |
| Salbutamol(albuterol) | Aerocrom, Aerolin, Airomir, Asmasal, Combivent, Duovent, Ventide, Ventodisks, Venotlin, Volmax | Non-reactive |
| Secobarbital | Seconal | Positive for Barbiturates BAR |
| Sennosides | Senokot | Non-reactive |
| Sertraline | Zoloft | Potential Positive for Benzodiazepines BZO |
| Sodium Valproate | Depakene, Depakote, Epilim | Non-reactive |
| Temazepam | Restoril | Positive for Benzodiazepines BZO |
| Testosterone | Andropatch, Restandol, Sustanon, Virormone, slang name "anabolic steroids" | Non-reactive |
| Thioridazine | Mellaril | Non-reactive |
| Thyroxine Sodium | Eltroxin | Non-reactive |
| Tramadol | Tramake, Ultram, Zamadol, Zydol | Non-reactive |
| Trazodone | Desyrel, Molipaxin, Trialodine | Non-reactive |
| Triazolam | Halcion | Positive for Benzodiazepines BZO |
| Valporic Acid | Depakene | Non-reactive |
| Venlafaxine | Effexor, Effexor XL | Potential Positive for Phencyclidine PCP |
| Warfarin Sodium | Coumadin, Marevan | Non-reactive |
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