The onset effects of LSD typically take around 30 minutest to an hour and can last anywhere from 4 – 12 hours depending on the dosage. Users have often described the experience as a “trip” and report mind-altering hallucinations and sensations. Audio and visual senses can be heightened or distorted leaving users to feel detached from reality.

The effects of Ketamine are felt rapidly and often last anywhere from 30 minutes to 2 hours.  Onset effects are typically slower when ingested orally.  Users have reported flashbacks, or a sudden and vivid memory of a Ketamine “trip”, occurring several weeks after they have used. Drugs with similar effects include, LSD, PCP, GHB, and Rohypnol.

The effects of heroin or much like other opioids in that it produces the pain relieving euphoric effects but due to the fact that heroin is more often injected the effects are much more rapid and users have described the feeling of a “rush” of euphoria followed by a sleepy wakefulness that can last for hours. Since the effects are so intense and rapid it creates a very high potential for abuse and dependency. When a user begins taking heroin, like other opioids, the body will build a tolerance for the drug.  Users will eventually need to take larger and larger doses to achieve the “rush” or effects that they desire. This can lead to detrimental health effects and possible overdose or death.

The onset effects of GHB usually take around 15-30 minutes to appear and can last anywhere from 4-6 hours. Given it’s central nervous system depressant effects users can experience euphoric.