Oxycodone

OXY

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Primary Products

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DrugSURE® Integrated Test Cups

$

DrugSURE® Dip Tests

$

OralTox® Oral Fluid Tests

ng/ml

Cut-Off Levels

Rapid Urine Test: 20, 100 ng/mL

Rapid Oral Fluid Test: 5 ng/mL

WOD

Window of Detection Times

Urine Specimen: 1 – 3 Days

Oral Fluid Specimen: 48 Hours

What is Oxycodone?

Oxycodone is a semi-synthetic opioid medication derived from thebaine and used medically for moderate to severe pain management. It is available in immediate-release and extended-release formulations (e.g., OxyContin®, Roxicodone®), and typically appears as tablets or capsules in various colors, sizes, and imprints depending on manufacturer. In clinical use, it is taken orally under strict medical supervision due to its high abuse potential.

Recreationally, oxycodone may be swallowed, crushed and snorted, or—in more serious misuse cases—dissolved and injected to intensify its euphoric and sedative effects. Because it directly activates the brain’s opioid receptors, oxycodone carries significant risks for dependence, respiratory depression, overdose, and transition to stronger illicit opioids if misused.

Effects:

Pain relief and relaxation
Euphoria or a sense of well-being
Drowsiness and sedation
Slowed breathing and respiratory depression
Constricted “pinpoint” pupils
Nausea or vomiting
Itching or flushed skin
Impaired coordination and slowed reaction time
Constipation
High risk of tolerance, dependence, and withdrawal symptoms

Commons Slang Terms:

Oxy
Oxys
OC
Percs / Percocets
Hillbilly heroin
Blues (for certain 30 mg tablets)
Roxy / Roxies
80s (referring to OxyContin® 80 mg, historically)

Legal Status:

Oxycodone is classified as a Schedule II controlled substance in the United States, meaning it is legal only with a valid prescription but has a high potential for abuse, addiction, and diversion. Because of this scheduling, oxycodone is routinely included in standard drug-testing panels for workplaces, treatment programs, court-ordered monitoring, and other supervised environments.

In point-of-care (POC) rapid toxicology testing programs, oxycodone often requires its own dedicated test line, as standard opiate screens may not reliably detect it due to its chemical structure. This makes targeted oxycodone assays valuable for identifying misuse versus prescribed medical use. Any presumptive positive at the POC level typically requires laboratory confirmation to verify accuracy and to distinguish legitimate prescriptions from non-medical use.

Its controlled status also means that programs must document prescription disclosures, maintain strict chain-of-custody procedures, and apply consistent policies when evaluating positive results to ensure compliance with federal and employer standards.