Gabapentin

GAB

Primary Products

$

DrugSURE® Integrated Test Cups

$

DrugSURE® Dip Tests

$

OralTox® Oral Fluid Tests

ng/ml

Cut-Off Levels

Rapid Urine Test: 1,000, 2,000 ng/mL

Rapid Oral Fluid Test: 25 ng/mL

WOD

Window of Detection Times

Urine Specimen: 1 – 3 Days

Oral Fluid Specimen: 48 Hours

What is Gabapentin?

Gabapentin is a prescription medication classified as an anticonvulsant and neuropathic pain agent. It works by modulating certain neurotransmitters to reduce nerve-related pain and stabilize electrical activity in the brain. Medically, it is FDA-approved for treating seizures and postherpetic neuralgia, and is widely prescribed off-label for conditions such as anxiety, fibromyalgia, restless leg syndrome, and general nerve pain.

Gabapentin typically comes in capsules, tablets, or oral solutions. Capsules may be white, yellow, or multicolored depending on strength and manufacturer. Tablets may be scored or film-coated and usually display the dose or manufacturer imprint.

Medically, gabapentin is taken orally in controlled doses. Recreational misuse has increased in recent years, often combined with opioids, sedatives, or alcohol to enhance sedating or euphoric effects. On its own, gabapentin may produce relaxation, mild dissociation, or sedation in high doses. Misuse is most common in populations with substance use disorders due to its ability to potentiate other depressants, despite being traditionally viewed as a low-risk medication.

Effects:

  • Sedation and drowsiness

  • Dizziness or lightheadedness

  • Relaxation and reduced anxiety

  • Mild euphoria in high doses

  • Impaired coordination or slowed motor skills

  • Blurry or double vision

  • Confusion or slowed cognition

  • Swelling in extremities (edema)

  • Nausea or gastrointestinal discomfort

  • Increased risk of respiratory depression when combined with opioids or alcohol

Commons Slang Terms:

  • Gabbies / Gabbies

  • Johnnies

  • Gabba

  • Nerves (street shorthand referencing its nerve-pain use)

  • Penguin pills

  • G-Pins / Pins

Legal Status:

Gabapentin is not federally scheduled under the U.S. Controlled Substances Act. However, due to increasing misuse and involvement in polysubstance overdoses, multiple states (including KY, TN, WV, VA, and others) have reclassified gabapentin as a Schedule V or controlled/monitored prescription drug, requiring enhanced oversight and reporting.

In point-of-care toxicology programs, gabapentin’s legal status impacts testing in several ways:

  • Because it is not a federally controlled substance, gabapentin is not part of standard workplace drug panels and is not required in DOT or other federal testing programs.

  • Rehabilitation, corrections, pain-management, and MAT programs often choose to test for it voluntarily due to its misuse potential and its interaction with opioids.

  • A positive gabapentin result typically requires careful interpretation since many individuals have legitimate prescriptions. Programs must incorporate prescription verification and confirmatory laboratory testing into their workflow.

  • Its emerging status as a drug of concern means more POC devices are beginning to include gabapentin as an optional test parameter in expanded panels.

Screening Options:

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