Cocaine

COC

Primary Products

$

DrugSURE® Integrated Test Cups

$

DrugSURE® Dip Tests

$

OralTox® Oral Fluid Tests

ng/ml

Cut-Off Levels

Rapid Urine Test: 100, 150, 300, 500 ng/mL

Rapid Oral Fluid Test: 8 ng/mL

WOD

Window of Detection Times

Urine Specimen: 1 – 3 Days

Oral Fluid Specimen: 48 Hours

What is Cocaine?

Cocaine is a powerful central nervous system stimulant derived from the leaves of the coca plant. It rapidly increases dopamine levels in the brain, producing intense euphoria, heightened alertness, and a short-lived but highly reinforcing sense of energy. Pharmaceutical-grade cocaine exists in limited medical contexts (such as topical anesthesia for certain ENT procedures), but nearly all cocaine encountered in the United States is illicit and unregulated.

In its powdered form (cocaine hydrochloride), it typically appears as a fine white crystalline powder that is snorted, rubbed onto gums, or dissolved and injected. Another form, crack cocaine, is produced by processing the powder with baking soda or other agents to create small “rocks” that can be smoked, delivering a faster and more intense high. Because illicit cocaine is frequently adulterated with substances like levamisole, fentanyl, or local anesthetics, users face increased health risks beyond the effects of the drug itself.

Recreational cocaine use is associated with patterns of bingeing, addiction, cardiovascular complications, and significant behavioral changes. Its highly addictive nature, rapid onset, and short duration make it a major substance of concern across emergency departments, workplace testing programs, criminal justice systems, and treatment centers.

Effects:

  • Intense euphoria and elevated mood

  • Increased energy, alertness, and confidence

  • Decreased appetite

  • Dilated pupils

  • Elevated heart rate, blood pressure, and body temperature

  • Restlessness, agitation, or anxiety

  • Insomnia and repetitive behaviors

  • Increased risk of heart attack, stroke, or cardiac arrhythmias

  • Strong cravings and high addiction potential

  • Paranoia, aggression, or hallucinations at higher doses or during binges

Commons Slang Terms:

  • Coke

  • Blow

  • Snow

  • White

  • Nose candy

  • Yayo

  • Powder

  • Flake

  • Rock (refers to crack cocaine form)

  • Base (also crack form)

Legal Status:

Cocaine is classified as a Schedule II controlled substance under the U.S. Controlled Substances Act—meaning it has extremely limited medical use but a very high potential for abuse. Practically, any cocaine use outside of narrow medical applications is illegal. This classification places cocaine on nearly all standard drug testing panels, including point-of-care (POC) rapid toxicology devices used by workplaces, treatment facilities, and government monitoring programs.

For testing programs, cocaine is one of the core mandated analytes in federal workplace drug testing (including DOT-regulated industries). Its rapid metabolism but distinctive metabolite (benzoylecgonine) makes it highly suitable for urine and oral fluid screening, enabling programs to detect use within a relatively short window after exposure. Positive POC screens typically require confirmatory laboratory testing to verify presence and rule out cross-reactivity.

Because cocaine has no legitimate outpatient prescription use, positive results in workplace or government-operated programs generally indicate illicit use and carry significant compliance, employment, or legal consequences. This absence of medically justified prescriptions simplifies interpretation compared to substances like amphetamines or benzodiazepines.

Screening Options:

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