ng/ml

Cut-Off Levels

Urine Specimen: 100 ng/mL

WOD

Window of Detection Times

Urine Specimen: 1 – 3 Days

What is Clonazepam?

Clonazepam is a prescription benzodiazepine commonly used to treat seizure disorders, panic disorder, and certain anxiety conditions. It works by enhancing the effect of GABA, the brain’s primary inhibitory neurotransmitter, producing calming, sedative, and anti-convulsant effects. In medical form, clonazepam typically appears as small tablets or disintegrating tablets in various colors depending on dosage strength. Because of its potency and long half-life, it is carefully dosed and monitored under medical supervision.

Outside of medical use, clonazepam can be misused for its relaxing and euphoric effects, or to intensify or counteract the effects of other substances. Recreational misuse often involves taking higher-than-prescribed doses or combining it with alcohol or opioids, which significantly increases overdose risk due to respiratory depression. Illicitly, the drug may also appear as counterfeit pills meant to mimic pharmaceutical tablets, posing additional dangers due to unknown strength or adulterants.

In toxicology settings, clonazepam poses challenges because its primary metabolites—especially 7-Aminoclonazepam—are the compounds detected in urine. This requires targeted assays or confirmatory laboratory testing for accurate identification

Effects:

  • Sedation and drowsiness

  • Reduced anxiety and muscle tension

  • Impaired coordination and slowed reaction time

  • Memory impairment or difficulty concentrating

  • Dizziness or lightheadedness

  • Slurred speech

  • Dependence and withdrawal risk with repeated use

  • Respiratory depression, especially when mixed with alcohol or opioids

  • Mood changes, irritability, or emotional blunting

  • Potential for overdose when misused or taken in high doses

Commons Slang Terms:

  • K-pin / Kpin

  • Pin

  • Super Valium

  • Benzos

  • Downers

  • Chill pills

  • Tranks

Legal Status:

Clonazepam is classified as a Schedule IV controlled substance in the United States, indicating legitimate medical use but a meaningful risk of misuse or dependence. Because of this classification, benzodiazepines—including clonazepam—are routinely included in many rapid toxicology screening programs across workplace testing, treatment centers, probation programs, and clinical environments.

However, clonazepam presents a unique challenge for point-of-care tests: standard benzodiazepine immunoassays do not always reliably detect clonazepam because its major metabolite, 7-Aminoclonazepam, has weaker cross-reactivity on many rapid test strips. As a result, a person taking clonazepam may screen negative on a basic rapid test, requiring programs to rely on confirmatory laboratory testing (GC/MS or LC/MS) for accurate identification when clonazepam use is suspected or needs verification.

For testing programs, clear policies are needed regarding prescription disclosure, confirmation protocols, and interpretation of benzodiazepine screening results to ensure accuracy and compliance with regulatory expectations.

Screening Options:

Forensic Use Only

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Lab Confirmation Services Available

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