Benzodiazepine
BZO
What is Benzodiazepine?
Benzodiazepines are a class of central nervous system depressants that act by enhancing the neurotransmitter GABA, producing calming effects such as reduced anxiety, muscle relaxation, and sedation. Medically, they are widely prescribed for anxiety disorders, insomnia, muscle spasms, seizure control, and alcohol-withdrawal management. Common prescription examples include Xanax® (alprazolam), Valium® (diazepam), Klonopin® (clonazepam), Ativan® (lorazepam), and Restoril® (temazepam).
Pharmaceutical benzodiazepines typically come as tablets, capsules, liquid solutions, or occasionally injectable formulations used in clinical settings. Illicitly misused benzodiazepines may appear as diverted prescription pills or counterfeit tablets produced to resemble pharmaceutical products. Recreational use often involves taking higher-than-prescribed doses to achieve sedation, euphoria, or potentiation of other substances, particularly opioids and alcohol, which drastically increases overdose risk. Benzodiazepines are associated with dependence, withdrawal, and impaired cognitive and motor function, especially with long-term misuse.
Effects:
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Sedation and drowsiness
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Reduced anxiety and muscle tension
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Impaired coordination and slowed reaction time
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Memory impairment or “blackouts”
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Slurred speech
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Confusion or cognitive slowing
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Dizziness or loss of balance
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Respiratory depression (especially with opioids or alcohol)
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Risk of dependence and withdrawal symptoms
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Emotional blunting or flattened affect
Commons Slang Terms:
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Benzos
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Bars (often referring to Xanax)
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Zannies / Xannies
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Downers
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Tranks
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Blues (often referring to 10 mg Valium tablets)
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Vallies (Valium)
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Klonies (Klonopin)
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Footballs (oval Xanax pills)
Legal Status:
Benzodiazepines are classified as Schedule IV controlled substances in the U.S. Controlled Substances Act, meaning they have legitimate medical uses but still present a risk for misuse, dependence, and diversion. Because they are commonly prescribed yet frequently misused—especially in combination with opioids—benzodiazepines are one of the core drug classes included in most point-of-care (POC) rapid toxicology test panels.
In workplace, treatment, and government-run programs, their Schedule IV status requires programs to distinguish between legitimate prescription use and unauthorized consumption. A positive rapid screen for benzodiazepines typically triggers confirmation testing to verify the specific medication and concentration. Testing programs must also have clear policies allowing individuals to provide proof of a valid prescription while also identifying unsafe, illicit, or impaired use. In regulated or safety-sensitive settings, detecting non-prescribed benzodiazepine use is critical due to the drug’s strong impairing effects on cognition, coordination, and reaction time.
Screening Options:
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